E-ISBN: Publication Year: 2015
Binding: Paper Back Dimension: 185mm x 240mm Weight: 1053
About the book
ESSENTIALS OF MOLECULAR GENETICS is primarily designed as a text book for undergraduate students studying molecular genetics. It provides concise yet complete knowledge on the nature, structure, molecular forms, location, organization, packaging, recombination, damage, transposition, repair, protection of genetic material; gene structure, gene organization, gene function, transcription, RNA processing, genetic code, translation, and fate of finished proteins, ribosomes, and used messenger RNAs; and molecular mechanisms of regulation of gene expression in viruses, bacteria and eukaryotes, role of epigenetic modifications in gene regulation, role of DNA and histone modification, and noncoding RNAs and gene silencing in bacteria, viruses and eukaryotes.
The book also deals with various molecular tools, techniques and technologies DNA/RNA separation, in situ hybridization, squash dot hybridization, southern blotting, northern blotting, western blotting, eastern blotting, dot blot, slot blot, electrophoresis, colony hybridization, plaque hybridization, chromosome walking, chromosome jumping/hopping, chromosome landing, nick translation, RNA sequencing, DNA sequencing, RNA synthesis, DNA synthesis, DNA synthesis machines, DNA fingerprinting, DNA markers, microarrays, restriction endonucleases, recombinant DNA technology, and quantitative trait loci mapping, methods for detection of mutations, site-directed mutagenesis, Smiths gene knockout technique, transposon mutagenesis, antisense molecules, hybrid arrested translation, hybrid released translation, transcriptomic analyses, proteomic analyses, etc. frequently used in molecular genetic studies.
A brief historical background for every chapter
A concise yet complete treatise covering essential aspects of molecular genetics
Recent progresses discussed
Nobel Prize winning work finds a special mention
Simple and lucid language
Supported by 1360 references, 71 tables, and 402 figures
Terms defined in context of the present day knowledge
Separate section on glossary of important terms
Thought provoking problems at the end of each chapter to test comprehension
Applications/implications of various discoveries pin-pointed
Useful for national and international level competitive examinations, entrance tests, and interviews
Detailed subject index
Table of Contents
Foreword / Preface / Introduction / Nature of the Genetic Material / Structure of the Genetic Material / Extranuclear Genomes / Organization of the Genetic Material / Packaging of Nucleic Acids / Replication of Nucleic Acids / Genetic Recombination / Mutation / DNA Transposition / DNA and Non-DNA Repair Mechanisms / Gene Structure / Defense Genes / Gene Organization / Gene Function / Transcription / RNA Processing and RNA Editing / Genetic Code / Protein Biosynthesis / Fate of Nascent Proteins, Ribosomes, and Messenger RNAs / Gene Expression Analysis / Gene Regulation in Bacteria / Gene Regulation in Viruses / Gene Regulation in Eukaryotes / Epigenetics / Noncoding RNAs and Gene Silencing / Molecular Techniques and Tools / Glossary / Subject Index.